Baseball
Buddy Bell – former third baseman and manager
David Bell – son of Buddy Bell; professional baseball player
Mike Bell – son of Buddy Bell and brother of David Bell; former third baseman for the Cincinnati Reds
Andrew Brackman – professional baseball player
Ken Griffey, Jr. – former outfielder/designated hitter for the Seattle Mariners, Cincinnati Reds and Chicago White Sox
Adam Hyzdu – professional baseball player
Barry Larkin – former shortstop for the Cincinnati Reds and National Baseball Hall of Fame member
Stephen Larkin – brother of Barry Larkin; former 1st baseman for the Cincinnati Reds
Bill Long – professional baseball player
Len Matuszek – major league outfielder and first baseman
Eric Surkamp - professional baseball player
Basketball
Byron Larkin – college basketball player, Xavier University's all-time leading scorer
Mike Sylvester – college and pro basketball player, University of Dayton
Football
Doug Williams – Lexington All-American and professional football NFL Houston Oilers offensive tackle
Bob Crable (1978) – Notre Dame All-American and professional football linebacker
Russ Huesman – head college football coach for the Chattanooga Mocs
Greg Jones – linebacker, Tennessee Titans; All-American at Michigan State; Super Bowl XLVI champion
Mark Kamphaus – Arena Football League quarterback, Albany Firebirds
Michael Muñoz – college football offensive lineman; son of Anthony Muñoz
Rob Murphy – 2 time All-American offensive lineman at The Ohio State University, 6 years in the NFL, 6 years in the CFL
Doug Rosfeld – former University of Cincinnati and NFL football player for the Cleveland Browns; now a history teacher at Moeller
Matt Tennant – 2010 5th-round pick of the New Orleans Saints out of Boston College
Tom Waddle – professional football player for the Chicago Bears. Radio personality on ESPN 1000 AM in Chicago
Greg Hudson — Assistant Defensive Coordinator and Linebackers Coach — Florida State University
Rico Murray - Undrafted free agent signee by the Cincinnati Bengals.
Tony Hunter -professional football player for Buffalo Bills and Los Angeles Rams. 12th pick in first round of 1983 NFL draft. Varsity captain in football, track, and basketball.
Greg Huntington – American football player
Steve Apke – American football player
And, don't forget John Boehner, Speaker of the House. He played linebacker for the Crusaders.