I'm not familiar enough with women's cbb to call it one of the biggest upset's in history. #5 seed Louisville beating the world beater #1 seed Baylor in the 2013 NCAA tourney will be tough to beat. Baylor had Bradley Griner and that Baylor coach who is a *itch.
UW was ranked #103 by Massey. ORSt ranked #8 was a 16.5 favorite. I suspect there have been quite a few bigger favs than 16.5 that have been upset over the years. But it's still a stunner.