COVID-19

[InKellyWeTrust]

The HIV drug Leronlimab has shown great promise in treating moderate to severe Covid patients. Small sample, but no fatalities. Most patients were on oxygen or intubated at beginning of drug trial. Hearing about the drug out here in the West because that is where a good portion of tests are being conducted. Probably not getting the national exposure because it is not owned by a large company like Gilead or testing being conducted by Dr. Fauci like remdesivir.

https://finance.yahoo.com/news/cytodyn-reports-strong-results-eind-100010692.html

Sample size is the biggest issue. Need more data points. This is a very promising medication too. We discussed CCR5 inhibitors and BTK inhibitors earlier in this thread somewhere. There are many promising therapies. Nobody ever said the researchers are shutting up shop after the Remdesivir study. Also anything with "mab" in the name is a monoclonal antibody and pretty damn expensive to make - also a factor for widespread use.

I don't understand why everyone is so skeptical of the Fauci and the medical community at large having some sort of secondary gain from encouraging the use of Remdesivir. The study is large and shows pretty clear benefit. It is the only medication so far that has shown statistically significant benefit in a RCT sufficiently large, at least to my knowledge. Also, it was used mainly on patients with advanced disease. Most antivirals such as Remdesivir have greatest effect when used early in the disease course. So its easy to hypothesize even better outcomes when given earlier in disease course. One big issue with Remdesevir - it can only be given IV making it very difficult to use in the outpatient setting.

 

[Legacy]

So four out of 5000 end up in the hospital? They probably have worse outcomes on normal shore leave. 80% don't contract the virus in close quarters with no "distancing" let alone PPE.

The last figures were six from the ship to a hospital. I don't know how many from those quarantined were hospitalized. I've seen figures that one in four infected people are asymptomatic. COVID-19: What proportion are asymptomatic? But the Roosevelt with that group of younger, healthy population with 100% testing evidences at 50% were asymptomatic carriers after two weeks of their deployment from Vietnam. Clearly, mitigation measures once they reached Guam undoubtedly prevented further infection. I also assume that the sailors were notified to report any symptoms, had access to testing and to medical facilities and expertise on the ship.

Testing and follow-up is key to document how many of the asymptomatic - or pre-symptomatic - carriers later test positive. This fits with the conclusions that younger, healthier people probably with good nutrition have a low rate of hospitalizations and mortality even in a closed system and close quarters. That may bode well for future herd immunity among this population.

Other confined populations as on the cruise ships with older and more with chronic diseases may not fare as well and may have increased infection rates due to multiple disembarkations.

At least with the Roosevelt, you do not have the asymptomatic carriers mingling with those older with chronic diseases which increase the rates of hospitalization and mortality. Those situations may also arise in public transportation like subways, etc. or businesses or in highly vulnerable populations like nursing or veterans homes.

The other takeaway for me is how the Navy needed to extend quaranteens for three weeks due to positive testing in those previously negative at the end of two week period.

 

[Valpodoc85]

Hot take:

Covid is a poly-factorial illness. What I mean is covid by itself is not very virulent. Covid plus something else...different story. Microbiome are the germs that live on you and in you. It tends to be specific to a person but also regionally specific. So covid plus a germ living in you (maybe respiratory, maybe GI) causes a broader spectrum of disease. This would explain differences in places like New York, the Lombardy region of italy and Wuhan.
Genetics has been suggested as a cause but New York is one of the most diverse genetic populations on the planet.
Just a thought

 

[Pops Freshenmeyer]

Hot take:

Covid is a poly-factorial illness. What I mean is covid by itself is not very virulent. Covid plus something else...different story. Microbiome are the germs that live on you and in you. It tends to be specific to a person but also regionally specific. So covid plus a germ living in you (maybe respiratory, maybe GI) causes a broader spectrum of disease. This would explain differences in places like New York, the Lombardy region of italy and Wuhan.
Genetics has been suggested as a cause but New York is one of the most diverse genetic populations on the planet.
Just a thought

As a layperson that makes sense to me. Has there been any attempt to track or spot regional variation in symptoms?

 

[Valpodoc85]

Loads of smart people globally working on and generating data sets.

 

[SonofOahu]

Hot take:

Covid is a poly-factorial illness. What I mean is covid by itself is not very virulent. Covid plus something else...different story. Microbiome are the germs that live on you and in you. It tends to be specific to a person but also regionally specific. So covid plus a germ living in you (maybe respiratory, maybe GI) causes a broader spectrum of disease. This would explain differences in places like New York, the Lombardy region of italy and Wuhan.
Genetics has been suggested as a cause but New York is one of the most diverse genetic populations on the planet.
Just a thought

This is interesting. Are there other viruses like this?

Follow-up question: do you think this could lead to some sort of genetic drift?

 

[Valpodoc85]

Certainly understood that microbiome should be considered an organ system unto itself (think liver, kidney etc). There is research that microbiome can cause anxiety and depression. It has been recognized that Sendai virus and Pasteurella behave synergistically. Also bacteria like staph acquire drug resistance using plasmids (these are virus like). A good microbiologist can probably answer the question better

 

[Circa]

This is interesting. Are there other viruses like this?

Follow-up question: do you think this could lead to some sort of genetic drift?

I'm not sure what you are referring to. Genetic Viruses do not exist. This odd time, has shown more evidence than any in our human history of the man made manipulation of vaccines and viruses... Prove me wrong.

 

[Valpodoc85]

By definition a virus is rna or dna usually encapsulated in protein that requires another life form for reproduction

 

[Valpodoc85]

Follow up to Oahu, genetic drift is the inevitable product of variation. I do not believe the virus makes other organisms behave in a more virulent fashion. I believe the virus creates the conditions for bacteria to be more virulent or more likely vise versa. The other option is protection from the virus by specific germs. Kind of like you can have a bunch of people in a room but it’s not a party till someone brings the alcohol

 

[Circa]

Hot take:

Covid is a poly-factorial illness. What I mean is covid by itself is not very virulent. Covid plus something else...different story. Microbiome are the germs that live on you and in you. It tends to be specific to a person but also regionally specific. So covid plus a germ living in you (maybe respiratory, maybe GI) causes a broader spectrum of disease. This would explain differences in places like New York, the Lombardy region of italy and Wuhan.
Genetics has been suggested as a cause but New York is one of the most diverse genetic populations on the planet.
Just a thought

I don't understand 5G at all,... but some say the reasons are radiological. Why would the hot spots for the up ramp of 5g that most say doesn't exist coincide?
Issues that also occur with and have the highest rates of problematic viral symptoms? We could and should start understanding... ground up monkey parts and people that allow the neurological issue of vaccinations and vaccines that are harming us on the up and up....also..... I guess I'm asking people that are smart.



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[Valpodoc85]

Disclaimer:I'm not an electrical eginerd. 5G is just microwaves with a bandwidth capable of greater download speeds. Something like 3 Ghertz. They have been used for years in other applications, for ground control radio I think. South Korea has been the most aggressive with rollout and seems to have a really low covid mortality

 

[Circa]

A virus,... Is the common cold. The people that study these things have already stated years ago the facts of a Virus. There is no cure. Now people with power are trying to put Coronavirus into the English language as Covid 19. Then, they can claim It's a "Disease".

The Flu vaccine is a joke in and of itself, and why we are allowing ourselves to accept this lie.... is astonishing to the human race.

In the entire History of our existence as a human being there has never been a cure for any virus.

Keep wearing your Nazi masks.....

 

[Valpodoc85]

That is just false. Vaccines give you a way to make antibodies so you don’t get sick. See polio, small pox etc. then there are all the antiviral drugs. Yes they work and can “cure” you.

 

[Irishize]

https://www.nytimes.com/2020/04/30/opinion/coronavirus-treatment.html

 

[yankeehater]

https://www.nytimes.com/2020/04/30/opinion/coronavirus-treatment.html

Here are the doctors findings from the Leronlimab study and why they believe it is working versus the other HIV drugs mentioned. Also in their HIV trials 850 patients and 0 serious side effects with drug unlike some of the other drugs now being tried on Covid patients. As I read more about the Covid trial, their group sample not only was with some of the most serious Covid patients, but also with serious pre-existing conditions like multiple organ donor recipients. Basically, they took on the ND Football schedule instead of an SEC non-conference schedule.
Fox now has an artilce up on this drug on their website.

CytoDyn scientists believe their studies show that powerful immune modulator RANTES drives the pathogenic process of COVID-19.

--RANTES is chemoactive chemokine, expressed by many hematopoietic and non-hematopoietic cell types, that plays key role in controlling homing and migration of effector and memory T-cells during acute infections.

--RANTES receptor (CCR5) is co-receptor for HIV and a major target of anti-HIV drugs based on blocking viral entry.

--RANTES levels are highly elevated in COVID-19 patients and RANTES fundamentally drives the COVID-19 pathogenic process via binding of RANTES to CCR5.

--CytoDyn’s drug, a humanized monoclonal antibody called leronlimab, blocks CCR5, denying binding access to RANTES.

--Levels of RANTES return to normal very quickly after single sub-cutaneous injection of leronlimab

--Disease-associated high levels of interleukin-6, and of other chemokines, are quickly reduced to normal.

--Lung function is restored.

--Plasma viral load is reduced.

--Drug delivered by one subcutaneous injection.

 

[Legacy]

In a less developed country one will observe the lines of people waiting to get vaccinated because they have observed the ravages of the diseases firsthand. They do this to protect their families including their elderly members.

I'm sure a year ago some people called de Blasio a fascist for mandating measles vaccinations in the Orthodox Jewish community - but he also had the support of their religious leaders who recognized the dangers with the need to educate. Public health officials warned of the deadly consequences when the chicken pox epidemic among them in 2016, especially for infants, pregnant women and anyone with compromised immune systems.

As far as coronavirus in that population,
For some US Jewish communities, serious outbreak linked to mass Purim parties (The Times of Israel)

Measles and chickenpox like SARS and Covid are viruses that are highly contagious and require airborne precautions that include isolation in a negative pressure room and n95 masks. HC personnel have clinical experience in ICU isolation for measles and chickenpox, though the units usually may have only one or two of these type rooms. Knowing that COVID requires the same precautions, that there is no vaccine and that the whole unit is full of COVID patients and that your only protection is a n95 mask while watching patients die of the disease can shake one's feeling of some degree of safety. In some places, ICU nurses who never have to care for more than two patients are assigned five. Should a vaccine-preventable disease like measles and chickenpox hospitalize an unvaccinated child who needs to come into that ICU full of COVID patients...

 

[Bishop2b5]

A virus,... Is the common cold. The people that study these things have already stated years ago the facts of a Virus. There is no cure. Now people with power are trying to put Coronavirus into the English language as Covid 19. Then, they can claim It's a "Disease".

The Flu vaccine is a joke in and of itself, and why we are allowing ourselves to accept this lie.... is astonishing to the human race.

In the entire History of our existance as a human being there has never been a cure for any virus.

Keep wearing your Nazi masks.....

Circa, I don't know where you've gotten your info or how you've come to these conclusions, but you are badly mistaken, my friend. There are a large number of virus-caused illnesses that wreaked havoc on people in the past, but have been all but eliminated by vaccines. Smallpox, measles, and polio are just a few, and the flu vaccine is very effective. I know you're sincere, but you've been misled and have some ideas on this matter that are simply wrong.

 

[Circa]

Circa, I don't know where you've gotten your info or how you've come to these conclusions, but you are badly mistaken, my friend. There are a large number of virus-caused illnesses that wreaked havoc on people in the past, but have been all but eliminated by vaccines. Smallpox, measles, and polio are just a few, and the flu vaccine is very effective. I know you're sincere, but you've been misled and have some ideas on this matter that are simply wrong.

I'll admit i am probably wrong and got some wires crossed on the whole vaccine idea. I've gone down a rabbit hole lately with this lockdown thing and i am personally trying to understand things. My opinion has no real relevance to the problem that we face today and I apologize if It's hit some sideways.

I agree with vaccines for most everything. The MMR vaccine has raised my eyebrows a bit and that shouldn't be my only bases for an opinion. It's not an easy subject to understand completely, one way or the other.

Autism has been something the CDC has known to be an antigen of the MMR vaccine and then been covered up, and when people have tried to come out (Whistle Blower), they are arrested and jailed until they either take the payoff and retract their findings or lose their careers and blackballed. This in and of itself should make everyone worried.

I'm no Dr. But I do read and listen to things the mainstream media Is paid to keep out of the public eye.

 

[Circa]

I found myself questioning things after listening to Dr. Judy. She opened my eyes up and I would recommend buying her book to anyone that wants to understand the crises that we are involved with today.

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https://www.amazon.com/Plague-Corruption-Restoring-Promise-Science-ebook/dp/B07S5H6T4Q

http://plaguethebook.com/

 

[TorontoGold]

I'll admit i am probably wrong and got some wires crossed on the whole vaccine idea. I've gone down a rabbit hole lately with this lockdown thing and i am personally trying to understand things. My opinion has no real relevance to the problem that we face today and I apologize if It's hit some sideways.

I agree with vaccines for most everything. The MMR vaccine has raised my eyebrows a bit and that shouldn't be my only bases for an opinion. It's not an easy subject to understand completely, one way or the other.

Autism has been something the CDC has known to be an antigen of the MMR vaccine and then been covered up, and when people have tried to come out (Whistle Blower), they are arrested and jailed until they either take the payoff and retract their findings or lose their careers and blackballed. This in and of itself should make everyone worried.

I'm no Dr. But I do read and listen to things the mainstream media Is paid to keep out of the public eye.

There is no legitimate study out there that supports the theory of a link between autism and vaccines. Entertaining this kind of thought is ridiculous, this isn't some sort of Big Gov or Big Pharma conspiracy. Look at the measles outbreaks that happen because of anti-vaxxer wingnuts.

 

[Circa]

There is no legitimate study out there that supports the theory of a link between autism and vaccines. Entertaining this kind of thought is ridiculous, this isn't some sort of Big Gov or Big Pharma conspiracy. Look at the measles outbreaks that happen because of anti-vaxxer wingnuts.

I beg you to research
Read and listen to the book/podcast I posted earlier. As I stated. The waters that we are walking on are uncharted, and the only study we the People know are the words that are encouraging money to switch hands on our taxpayer money.


https://www.amazon.com/Inoculated-S...05NA5FT43XC&psc=1&refRID=DY5DZG0VG05NA5FT43XC


https://www.amazon.com/Vaccine-Whis...W6AKWSRCTZS&psc=1&refRID=3AQ6W4PMHW6AKWSRCTZS

 

[BGIF]

MAY 1, 2020 / 3:19 PM / UPDATED 13 MINUTES AGO
FDA authorizes Remdesivir drug for COVID-19

WASHINGTON (Reuters) - President Donald Trump said on Friday the U.S. Food and Drug Administration (FDA) had granted authorization to Gilead Sciences Inc (GILD.O) for emergency use of its experimental antiviral drug Remdesivir to treat patients with COVID-19.

During a meeting in the Oval Office with the president, Gilead Chief Executive Daniel O’Day called the move an important first step and said the company was donating 1 million vials of the drug to help patients.

I watched the live report from the White House, Gilead is actually committed to 1.5 million vials or Remdesivir which amounts to about 150,000 patients treated on a 10 day regime. Some patients have been responded in 5 days which could mean for now that the more patients may see relief than the 150,000.

Keep in mind that this is a treatment not a cure but it's a first step against Covid 19. Right now the media is reporting that is FDA Approved. A doctor interviewed on Fox noted that Remdesivir is EUA, Emergency Use Authorized by the FDA for Covid 19. You can read the FDA Remdesivir EUA Fact Sheet at https://www.fda.gov/media/137565/download

Gilead is ramping up production of Remdesivir through subsidiary companies. They have also secured sources of raw materials in India. Previously Remdesivir raw materials came from China.

FTR, I'm not a medical professional. I'm a retired Civil/Environmental Engineer that happens to have about a dozen MD's in my extended family as well as a half dozen RNs, two PA, two PharmD's, two Physical Terrorist PhDs, and a pharmaceutical rep that works for ... Gilead. I've been a Gilead stockholder for about a half dozen years. And on that note before some of you rush to buy Gilead stock recognize they are donating these treatments and do not have an FDA Approved product to sell via pharmacies. Stock analysts have mixed emotions on how this will impact Gilead's earnings as they have spent a lot of money developing Remdesivir originally for Ebola where it was not successful and in the headlong push they made into work on Covid 19 with no compensation and at this point there's no product to market. One or more of the other pharmas working on similar treatments may come with a more effective treatment.

Meanwhile this is good news for Covid 19 patients ... and those of us may still become patients down the road.

Kudos to Gilead CEO Dan O'Day who has been on the job at Gilead for about one year and to Trump, Pence and their team who worked with private industry to make this happen.

 

[arahop]

Why is the White House blocking Fauchi from speaking to Congress?

 

[Circa]

Why is the White House blocking Fauchi from speaking to Congress?

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Might be something to what I've said here anyway.... Karma Is a reckoning...

 

[RallySonsOfND]

Why is the White House blocking Fauchi from speaking to Congress?

Probably for the same reasons they blocked any testimony during impeachment/investigation.

 

[Irish YJ]

Why is the White House blocking Fauchi from speaking to Congress?

Welp, knowing what dems did during the collusion delusion and Kav hearings, I wouldn't either. I wouldn't let anyone anywhere near Pelosi's "oversight" folks...

 

[TorontoGold]

Welp, knowing what dems did during the collusion delusion and Kav hearings, I wouldn't either. I wouldn't let anyone anywhere near Pelosi's "oversight" folks...

This is the most accessible administration in history.

 

[Irish YJ]

This is the most accessible administration in history.

Counting all the bogus investigation and oversight, I'm sure it has been. Guessing you're not up to speed on all the FISA abuses, and everything that's come to light on the dossier and investigations like that of Flynn and Page... Either that, or you fine with all of it...

 

[GATTACA!]

Counting all the bogus investigation and oversight, I'm sure it has been. Guessing you're not up to speed on all the FISA abuses, and everything that's come to light on the dossier and investigations like that of Flynn and Page... Either that, or you fine with all of it...

Gotta be on the lookout for the italics my man.