ND has a rough first round matchup with Utah who is electric on offense but if they avoid the upset bid (and they should) Hopkins at #6 is likely an easier road than a rematch with an improved Georgetown, an extremely talented by inconsistent Cornell, or a very well rounded Penn State.
Georgetown is good enough to upset UVA if they don’t get nipped by Yale. Really the only advantage to the #1 and #2 seeds are their first round matchups. The overall paths aren’t easier. If somehow ND avoids the UVA kryptonite then they should win it all because they have blown the doors off every other team they’ve seen this year.