In the big scheme of things that is not really that much money. If you account for her lawyers fees and taxes the amount she may receive will not be exactly enough for a woman like that to retire on.
Plaintiff's lawyers typically work on a contingency fee of 20-30%. Money won through a legal judgment is often exempt from taxation, since it's theoretically paid in compensation for a loss or injury.
She's suing the hotel for $6 million and the guy who video taped her for $4 million. It's highly unlikely that the peeping tom has that kind of money, but she might get a big chunk out of Marriott.
Anyone could live quite comfortably off $5 million + if invested properly, but that hardly means that Andrews will be quitting ESPN. Her job is the source of her celebrity, which brings lots of other opportunities to make money (photo shoots for Maxim, etc.)
She'll likely settle out of court with Marriott for an undisclosed amount and continue working for ESPN. Whether she pursues her claim against Michael Barrett probably depends on how vindictive she is and whether it hurts or helps her public image.