I wouldn't be surprised to see a Lester, Ellsbury, Masterson deal for Santana. With Hunter gone, the Twins need a centerfielder badly and I doubt they want to go after Andruw Jones with the money he will be requiring, therefore Ellsbury would be the perfect fit.
I don't know how I feel about that move though. I like Ellsbury from his postseason performance, but I know that he can't perform like that all season, so that is a hard one. With Lester you've got a kid who fought back from cancer to seal the World Series, thats a pretty big accomplishment there, and Masterson is a pretty good looking up and coming pitcher. However, Santana would do well in a Sox uni. With the offensive firepower behind him, his numbers could be better than with the Twins, though he is pitching in a hitter friendly ballpark.
I really don't know what I want the Sox to do here. I guess if I were the GM and the Twins came and said they were ready to pull the trigger on that deal I would go for it, Santana is a huge addition to any rotation and the Sox have the money to get him a deal to stick around for many more years. Just think about it...Beckett, Santana, Daisuke, Schilling, Bucholz. Thats a pretty nasty rotation, with Schilling being the only one that wouldn't be there long term. The Sox would become the Braves of the early and mid '90s except they have some bats as well.